Based or created in MN (U-V)
- United Health Group (Minnetonka) - one of the largest US healthcare corporations
- US Bancorp (Minneapolis) - sixth largest financial services holding company in the US
- Utne Magazine (Minneapolis) - founded in 1982 as a digest of articles from alternative media sources
- Valspar (Minneapolis) - sixth largest paint company in the world; in operation since 1806
